Just found a bug with TTW 2.7.2 version, where 'Red' the doctor of Big Town suddenly decides to move back into Germantown Police HQ Jail Cell after completing the 'Big Trouble in Big Town' quest by rescuing Red and Shorty and escorting both of them back into Big Town - I then taught the Big Town residents on how to use guns to defend themselves with and everything seemed to be fine after the quest completed.. But days of game time later on, when I returned there Red was no longer in Big Town - I tracked her down to her old prison cell in Germantown Police HQ, from where I had previously rescued her. For some odd unknown reason, Red seems to prefer a life of imprisonment to freedom in Big Town. I tried teleporting Red back to Big Town with console commands, but instead of resuming her normal activities in Big Town (being a town doctor), she immediately goes to walk off to get back to the prison cell she likes so much. (While she was temporarily brought back to Big Town by console, she had a functional dialogue option for trading medical supplies though). Note that Shorty has settled just fine to life in Big Town, it is only Red who has an obsession with prison cell.
Another more minor bug I recently found was right after the Broken Steel begins and the Lone Wanderer wakes up from two weeks of coma - Sentinel Sarah Lyons is supposed to be lying unconscious on a stretcher in the Citadel Infirmary, but instead she is standing up next to the stretcher while pretending to be unconscious (no dialogue etc), eyes shut and all.
My System essentials: i5 3570K, 8GB RAM, Win 7 Ultimate SP1 x64, SSD install.
Mods in use: Manual install TTW version 2.7.2 (no error messages of any kind during install) with optionals(TTW Anchorage Customization, TTW Bobbleheads, TTW Outcast Trading, TTW No Karma Followers, TTW XP Reduction, TTW More Cooking Items, TTW Speech Checks, TTW Reputation and TTW Stash Pack Options), plus other mods including TTW Interiors series of mods, TTW Alton IL Reloaded, texture packs (NMCs and Poco Bueno), TTW Equipment Looted when going to NV 1st time, More Enemies at Hoover Dam Final Battle, Power Armor Footstep Sounds, Perk Every Level, Level Cap 100, Enhanced Camera and TTW Realistic Wasteland Lighting.