I was trying to play through Zeta all day today and experienced regular crashes. Turning graphics all the way down seemed to help, but not much.
Specifically, the crashes are related to aliens, it seems. Whenever I am around aliens the chance of a crash goes way up. I have a hunch that it is sound related, they are trying to say something and its causing glitches, similar to the fawkes bug, but I can't find any empty sound files.
EDIT: Reopening this, I am experiencing a lot of crashes again, will test more and then share what I found.